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Author Carey, Nessa, author.

Title Junk DNA [OverDrive electronic resource] : a journey through the dark matter of the genome / Nessa Carey.

Publication Info. New York : Columbia University Press, [2015]
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Description 1 online resource
text file rda
eBook tlcgt
General tlctarget
Note Electronic book.
Summary For decades after the indentification of the structure of DNA, scientists focused only on genes, the regions of the genome that contain codes for the production of proteins. Other regions that make up 98 percent of the human genome were dismissed as "junk," sequences that serve no purpose. But researchers have recently discovered variations and modulations in this junk DNA that are involved with a number of intractable diseases. Our increasing knowledge of junk DNA has led to innovative research and treatment approaches that may finally ameliorate some of these conditions. Junk DNA can play vital and unanticipated roles in the control of gene expression, from fine-tuning individual genes to switching off entire chromosomes. These functions have forced scientists to revisit the very meaning of the word "gene" and have endangered a spirited scientific battle over whether or not this genomic "nonsense" is the source of human biological complexity. Drawing on her experience with leading scientific investigators in Europe and North America, Nessa Carey provides a clear and compelling introduction to junk DNA and its critical involvement in phenomena as diverse as genetic diseases, viral infections, sex determination in mammals, and evolution. We are only now unlocking the secrets of junk DNA, and Nessa Carey's book is an essential resource for navigating the history and controversies of this fast-growing, hotly disputed field. -- From dust jacket.
Contents An introduction to genomic dark matter -- Why dark matter matters -- When dark matter turns very dark indeed -- Where did all the genes go? -- Outstaying an invitation -- Everything shrinks when we get old -- Two is the perfect number -- Painting with junk -- Playing the long game -- Adding colour to the dark matter -- Why parents love junk -- Junk with a mission -- Switching it on, turning it up -- No man's land -- Project ENCODE : Big Science comes to junk DNA -- Headless queens, strange cats and portly mice -- Lost in untranslation -- Why LEGO is better than Airfix -- Mini can be mighty -- The drugs do work (sometimes) -- Some light in the darkness -- Appendix. Human diseases in which junk DNA has been implicated.
Reproduction Electronic reproduction. [S.l.] Columbia University Press 2015 Available via World Wide Web.
Subject Genomics.
Human genome.
Eukaryotic cells.
Recombinant DNA.
Insertion elements, DNA.
Non-coding RNA.
Gene therapy.
Genome, Human.
Eukaryotic cells. (OCoLC)fst00916456
Gene therapy. (OCoLC)fst00939638
Genomics. (OCoLC)fst00940228
Human genome. (OCoLC)fst00963101
Insertion elements, DNA. (OCoLC)fst00974201
Non-coding RNA. (OCoLC)fst01741020
Recombinant DNA. (OCoLC)fst01091466
Genre Electronic books.
Added Author OverDrive, Inc., distributor.
ISBN 9780231539418 (electronic bk.)
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