| Description |
1 online resource (xlv, 389 pages) : illustrations. |
| Series |
Woodhead Publishing Series in Biomedicine |
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Woodhead Publishing series in biomedicine.
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| Contents |
Cover; Drug-biomembrane interaction studies: The application ofcalorimetric techniques; Copyright; Dedication; Contents; Figures; Tables; List of abbreviations; Preface; About the editor and contributors; 1 Biological membranes and their role in physiopathological conditions; 1.1 Importance of drug- biomembrane interactions in biomedical and pharmaceutical research; 1.2 The structure of cell membranes; 1.3 Properties of plasma membranes; 1.4 Movement of molecules across the plasma membrane; 1.5 Functions of cell membranes; 1.6 Conclusion; 1.7 References; 1.8 Further reading. |
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2 Biomembrane models2.1 Introduction; 2.2 The fluid mosaic model of a biological membrane; 2.3 Lipid phases and lipid phase transitions; 2.4 Models of biological membranes and their applications; 2.5 Conclusion; 2.6 References; 3 Analytical methods for studying drug-biomembrane interactions; 3.1 Introduction; 3.2 Spectroscopic techniques; 3.3 Chromatographic methods; 3.4 Zeta potential measurement; 3.5 Microscopy techniques; 3.6 The Langmuir-Blodgett (LB) film balance technique; 3.7 Other techniques and mixed techniques; 3.8 Conclusions; 3.9 References. |
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4 Differential scanning calorimetry (DSC): theoretical fundamentals4.1 Introduction; 4.2 Brief survey of the main thermodynamic techniques; 4.3 Application to lipid systems; 4.4 Membrane partitioning and binding of additives; 4.5 The effects of additives on membrane properties; 4.6 Kinetic phenomena; 4.7 References; 5 DSC: history, instruments and devices; 5.1 Introduction; 5.2 History; 5.3 Instruments; 5.4 Special devices; 5.5 References; 5.6 Further reading; 6 DSC in drug-biomembrane interaction studies; 6.1 Introduction; 6.2 Aims and advantages of DSC; 6.3 Drug-biomembrane interactions. |
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6.4 Surfactants6.5 Genetic materials; 6.6 Polymers; 6.7 Drug delivery systems (DDSs); 6.8 Toxicity of biomolecules; 6.9 Conclusion; 6.10 References; 7 DSC applications: macromolecules; 7.1 Introduction; 7.2 Proteins; 7.3 Nucleic acids; 7.4 Polysaccharides; 7.5 Biopolymers; 7.6 Conclusion; 7.7 References; 8 DSC applications: nucleic acids and membrane interactions; 8.1 Introduction; 8.2 DNA-membrane interaction studies with DSC; 8.3 RNA-membrane interaction studies with DSC; 8.4 Conclusions; 8.5 References; 9 Nonsteroidal antiinflammatory drugs; 9.1 Introduction to antiinfl ammatory drugs. |
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9.2 The interaction of NSAIDs with biomembrane models9.3 NSAID-loaded DDSs; 9.4 Conclusion; 9.5 References; 10 Antimicrobial agents; 10.1 Introduction; 10.2 What are the appropriate biomembrane models for antimicrobial agents?; 10.3 Antivirals, virus envelopes, and biomembrane models; 10.4 Antifungals and biomembrane models; 10.5 Conclusion; 10.6 References; 11 Drug delivery systems: drug nanocarriers; 11.1 Introduction; 11.2 Drug delivery systems; 11.3 Experimental protocols; 11.4 Applications; 11.5 References; Appendix 1: General experimental setup of liposomal systems for DSC. |
| Note |
A1.1 Introduction. |
| Summary |
The design and development of drugs and new pharmaceutical formulations require a full characterization of the chemical and physicochemical events occurring at the level of the single active ingredients or excipients, as well as their reciprocal interaction. Thermal analysis techniques are among the most widely used methods to achieve this; among them, the Differential Scanning Calorimetry (DSC) technique, in which the thermotropic behaviour of a single substance or mixtures is analyzed as a function of a controlled temperature program. DSC is an accurate and rapid thermo-analytical technique, |
| Bibliography |
Includes bibliographical references and index. |
| Subject |
Pharmaceutical technology.
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Drugs -- Design.
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Biological models.
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Drug Design |
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Calorimetry -- methods |
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Membranes -- chemistry |
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Models, Biological |
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Technology, Pharmaceutical |
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Techniques pharmaceutiques. |
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Médicaments -- Conception. |
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Modèles biologiques. |
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Drugs -- Design |
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Biological models |
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Pharmaceutical technology |
| Genre |
Internet Resources. |
| Added Author |
Pignatello, Rosario, editor.
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| Other Form: |
Print version: Pignatello, R. Drug-Biomembrane Interaction Studies : The Application Of Calorimetric Techniques. Burlington : Elsevier Science, ©2013 9781907568053 |
| ISBN |
9781908818348 (electronic bk.) |
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1908818344 (electronic bk.) |
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1306176980 (ebk) |
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9781306176989 (ebk) |
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