| Description |
1 online resource (525 pages) : illustrations |
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data file rda |
| Summary |
"Based on the award-winning Wiley Encyclopedia of Chemical Biology published in 2008, this book explores the role of chemical biology in drug discovery and development. The first part of the book reviews key principles and techniques used in the design and evaluation of drug candidates. The second part elucidates biological mechanisms of certain diseases, illuminating approaches to investigate and target these diseases. Comprising carefully selected reprints from the Encyclopedia as well as new contributions from leading scholars in the field, this book provides researchers in academia and industry with important information to aid in the development of novel agents to treat disease"--Provided by publisher. |
| Bibliography |
Includes bibliographical references and index. |
| Contents |
Part I: Drug discovery and development. The role of chemical biology in drug discovery -- Computational approaches to drug discovery and development -- Design and selection of small molecule inhibitors -- Lead optimization in drug discovery -- Pharmacokinetics of drug candidates -- ADME properties of drugs -- Drug transport in living systems -- Blood-brain barrier: considerations in drug development and delivery -- Pharmacokinetic considerations: methods and systems of controlled drug delivery -- Pharmaceuticals: natural products and natural product models -- Part II: Chemical biology to understand and target disease. The role of chemical biology in understanding and treating disease: are small molecule "correctors" the way of the future? -- Anxiety disorders -- Chronic obstructive pulmonary disease (COPD) -- Depression -- Osteoarthritis -- Human immunodeficiency virus (HIV) -- Allergy and asthma -- Schizophrenia -- Protein misfolding and disease -- Protein trafficking diseases -- Metabolic diseases -- Mitochondrial medicine -- Lysosomal disorders. |
| Subject |
Biochemistry.
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Drug Discovery |
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Drug Delivery Systems |
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Biochemistry |
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Biochimie. |
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biochemistry. |
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Biochemistry |
| Added Author |
Civjan, Natanya, editor.
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| Other Form: |
Print version: Chemical biology. Hoboken, N.J. : Wiley, 2012 9781118101186 (DLC) 2012012322 (OCoLC)749857596 |
| ISBN |
9781118437674 (electronic bk.) |
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1118437675 (electronic bk.) |
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9781118435762 (electronic bk.) |
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1118435761 (electronic bk.) |
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9781118434505 (electronic bk.) |
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1118434501 (electronic bk.) |
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