| Description |
1 online resource (xxvi, 1035 pages, 32 unnumbered pages of plates) : illustrations (some color). |
| Series |
Methods of biochemical analysis ; v. 44 |
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Methods of biochemical analysis ; v. 44.
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| Bibliography |
Includes bibliographical references and index. |
| Contents |
Data Collection, Analysis, and Visualization -- Defining Bioinformatics and Structural Bioinformatics / Russ B. Altman, Jonathan M. Dugan -- Fundamentals of Protein Structure / Eric D. Scheef, J. Lynn Fink -- Fundamentals of DNA and RNA Structure / Stephen Neidle, Bohdan Schneider, Helen M. Berman -- Computational Aspects of High-Throughput Crystallographic Macromolecular Structure Determination / Paul D. Adams, Ralf W. Grosse-Kunstleve, Axel T. Brunger -- Macromolecular Structure Determination by NMR Spectroscopy / John L. Markley, Arash Bahrami, Hamid R. Eghbalnia, Francis C. Peterson, Robert C. Tyler, Eldon L. Ulrich, William M. Westler, Brian F. Volkman -- Electron Microscopy in the Context of Structural Systems Biology / Niels Volkmann, Dorit Hanein -- Study of Protein Three-Dimensional Structure and Dynamics Using Peptide Amide Hydrogen/Deuterium Exchange Mass Spectrometry (DXMS) and Chemical Cross-Linking With Mass Spectrometry to Constrain Molecular Modeling / Sheng Li, Dmitri Mouradov, Gordon King, Tong Liu, Ian Ross, Bostjan Kobe, Virgil L. Woods, Jr., Thomas Huber -- Search and Sampling in Structural Bioinformatics / Han Samish -- Molecular Visualization / Steven Bottomley, Erik Helmerhorst. |
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Data representation and databases -- The PDB Format, mmCIF Formats, and Other Data Formats / John D. Westbrook, Paula M.D. Fitzgerald -- The Worldwide Protein Data Bank / Helen M. Berman, Kim Henrick, Haruki Nakamura, John L. Markley -- The Nucleic Acid Database / Bohdan Schneider, Joanna de la Cruz, Zukang Feng, Li Chen, Shuchismita Dutta, Irina Persikova, John D. Westbrook, Huanwang Yang, Jasmine Young, Christine Zardecki, Helen M. Berman -- Other Structure-Based Databases / J. Lynn Fink, Helge Weissig, and Philip E. Bourne. |
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Data integrity and comparative features -- Structural Quality Assurance / Roman A. Laskowski -- The Impact of Local Accuracy in Protein and RNA Structures: Validation as an Active Tool / Jane S. Richardson, David C. Richardson -- Structure Comparison and Alignment / Marc A. Marti-Renom, Emidio Capriotti, Ilya N. Shindyalov, Philip E. Bourne -- Protein Structure Evolution and the SCOP Database / Raghu P.R. Metpally, Boojala V.B. Reddy -- The CATH Domain Structure Database / Frances M.G. Pearl, Alison Cuff, Christine A. Orengo. |
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Structural and functional assignment -- Secondary Structure Assignment / Claus A. Andersen, Burkhard Rost -- Identifying Structural Domains in Proteins / Stella Veretnik, Jenny Gu, Shoshana Wodak -- Inferring Protein Function from Structure / James D. Watson, Gail J. Bartlett, Janet M. Thornton -- Structural Annotation of Genomes / Adam J. Reid, Corin Yeats, Jonathan Lees, Christine A. Orengo -- Evolution Studied Using Protein Structure / Song Yang, Ruben Valas, Philip E. Bourne. |
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Macromolecular interactions -- Electrostatic Interactions / Nathan A. Baker, J. Andrew McCammon -- Prediction of Protein-Nucleic Acid Interactions / Timothy Robertson, Gabriele Varani -- Prediction of Protein-Protein Interactions from Evolutionary Information / Alfonso Valencia, Florencio Pazos -- Docking Methods, Ligand Design, and Validating Data Sets in the Structural Genomics Era / Natasja Brooijmans. |
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Structure prediction -- CASP and Other Community-Wide Assessments to Advance the Field of Structure Prediction / Jenny Gu, Philip E. Bourne -- Prediction of Protein Structure in 1D: Secondary Structure, Membrane Regions, and Solvent Accessibility / Burkhard Rost -- Homology Modeling / Hanka Venselaar, Elmar Krieger, Gert Vriend -- Fold Recognition Methods / Adam Godzik -- De Novo Protein Structure Prediction: Methods and Application / Kevin Drew, Dylan Chivian, Richard Bonneau -- RNA Structural Bioinformatics / Magdalena A. Jonikas, Alain Laederach, Russ B. Altman. |
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Therapeutic discovery -- Structural Bioinformatics in Drug Discovery / William R. Pitt, Alicia Perez Higueruelo, Colin R. Groom -- B-Cell Epitope Prediction / Julia V. Ponomarenko, Marc H.V. van Regenmortel. |
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Future Challenges -- Methods to Classify and Predict the Structure of Membrane Proteins / Marialuisa Pellegrini-Calace, Janet M. Thornton -- Protein Motion: Simulation / Ilan Samish, Jenny Gu, Michael L. Klein -- The Significance and Impacts of Protein Disorder and Conformational Variants / Jenny Gu, Vincent J. Hilser -- Protein Designability and Engineering / Nikolay V. Dokholyan -- Structural Genomics of Protein Superfamilies / Stephen K. Burley, Steven C. Almo, Jeffrey B. Bonanno -- Mark R. Chance, Spencer Emtage, Andras Fiser, Andrej Sali, J. Michael Sauder, Subramanyam Swaminathan. |
| Summary |
The second edition of this successful text expands on the depth and scope of the topic by bringing together many of the world's experts to provide a view of the current state of the field suitable for advanced undergraduate students, graduate students and beyond. The book begins with a description of the principles of protein, DNA and RNA structure, the methods used to collect the data, and how the data are represented, visualized and stored. With these prerequisites the comparative analysis of structure reveals classification schemes and how they are used in studies ranging from evolution to structure prediction. The physical properties of structure are explored to understand, for example, how macromolecules move and interact with each other and with ligands, offering insights into how drug discovery is undertaken and how structure can provide the details needed to understand complex molecular interactions important in fields such as immunology and systems biology. Finally, structural genomics reveals insight into the future role of structural bioinformatics where features, including function, are systematically assigned and the structural basis of complete organisms begin to emerge. |
| Subject |
Structural bioinformatics.
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Bioinformatics.
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Computational biology.
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Computational Biology |
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Molecular Biology |
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Bio-informatique structurale. |
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Bio-informatique. |
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Computational biology |
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Bioinformatics |
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Structural bioinformatics |
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Makromolekül |
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Molekulare Bioinformatik |
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Molekülstruktur |
| Genre |
Aufsatzsammlung. |
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Aufsatzsammlung.
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| Added Author |
Gu, Jenny.
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Bourne, Philip E.
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| Other Form: |
Print version: Structural bioinformatics. 2nd ed. Hoboken, N.J. : Wiley-Blackwell, ©2009 9780470181058 (DLC) 2008040419 (OCoLC)253189841 |
| ISBN |
9781613446140 (electronic bk.) |
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1613446144 (electronic bk.) |
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